Hypertrophy in Mesenchymal Stem Cell Chondrogenesis: Effect of TGF-β Isoforms and Chondrogenic Conditioning

Induction of chondrogenesis in mesenchymal stem cells (MSCs) with TGF-β leads to a hypertrophic phenotype. The hypertrophic maturation of the chondrocytes is dependent on the timed removal of TGF-β and sensitive to hypertrophy-promoting agents in vitro. In this study, we have investigated whether TG...

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Autori principali: Mueller, Michael B., Fischer, Maria, Zellner, Johannes, Berner, Arne, Dienstknecht, Thomas, Prantl, Lukas, Kujat, Richard, Nerlich, Michael, Tuan, Rocky S., Angele, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2010
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2968769/
https://ncbi.nlm.nih.gov/pubmed/20407224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000313399
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