TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation

BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage and was mirrored in vitro by addition of hypertr...

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發表在:Int J Stem Cells
Main Authors: Pfeifer, Christian G., Karl, Alexandra, Kerschbaum, Maximilian, Berner, Arne, Lang, Siegmund, Schupfner, Rupert, Koch, Matthias, Angele, Peter, Nerlich, Michael, Mueller, Michael B.
格式: Artigo
語言:Inglês
出版: Korean Society for Stem Cell Research 2019
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457698/
https://ncbi.nlm.nih.gov/pubmed/30836731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15283/ijsc18088
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