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Resistance gene-guided genome mining: Serial promoter exchanges in Aspergillus nidulans reveal the biosynthetic pathway for fellutamide B, a proteasome inhibitor

Fungal genome projects are revealing thousands of cryptic secondary metabolism (SM) biosynthetic gene clusters that encode pathways that potentially produce valuable compounds. Heterologous expression systems should allow these clusters to be expressed and their products obtained, but approaches are...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Yeh, Hsu-Hua, Ahuja, Manmeet, Chiang, Yi-Ming, Oakley, C. Elizabeth, Moore, Shauna, Yoon, Olivia, Hajovsky, Heather, Bok, Jin-Woo, Keller, Nancy P., Wang, Clay C. C., Oakley, Berl R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457343/
https://ncbi.nlm.nih.gov/pubmed/27294372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00213
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