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Resistance gene-guided genome mining: Serial promoter exchanges in Aspergillus nidulans reveal the biosynthetic pathway for fellutamide B, a proteasome inhibitor

Fungal genome projects are revealing thousands of cryptic secondary metabolism (SM) biosynthetic gene clusters that encode pathways that potentially produce valuable compounds. Heterologous expression systems should allow these clusters to be expressed and their products obtained, but approaches are...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:ACS Chem Biol
Main Authors: Yeh, Hsu-Hua, Ahuja, Manmeet, Chiang, Yi-Ming, Oakley, C. Elizabeth, Moore, Shauna, Yoon, Olivia, Hajovsky, Heather, Bok, Jin-Woo, Keller, Nancy P., Wang, Clay C. C., Oakley, Berl R.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457343/
https://ncbi.nlm.nih.gov/pubmed/27294372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00213
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