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Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin()
To reduce the secondary metabolite background in Aspergillus nidulans and minimize the rediscovery of compounds and pathway intermediates, we have created a “genetic dereplication” strain in which we have deleted eight of the most highly expressed secondary metabolite gene clusters (more than 244,00...
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| Pubblicato in: | Angew Chem Int Ed Engl |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4724294/ https://ncbi.nlm.nih.gov/pubmed/26563584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201507097 |
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