Hybrid Transcription Factor Engineering Activates the Silent Secondary Metabolite Gene Cluster for (+)-Asperlin in Aspergillus nidulans

Fungi are a major source of valuable bioactive secondary metabolites (SMs). These compounds are synthesized by enzymes encoded by genes that are clustered in the genome. The vast majority of SM biosynthetic gene clusters are not expressed under normal growth conditions, and their products are unknow...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Grau, Michelle F., Entwistle, Ruth, Chiang, Yi-Ming, Ahuja, Manmeet, Oakley, C. Elizabeth, Akashi, Tomohiro, Wang, Clay C. C., Todd, Richard B., Oakley, Berl R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546424/
https://ncbi.nlm.nih.gov/pubmed/30339758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00679
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