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Hybrid Transcription Factor Engineering Activates the Silent Secondary Metabolite Gene Cluster for (+)-Asperlin in Aspergillus nidulans

Fungi are a major source of valuable bioactive secondary metabolites (SMs). These compounds are synthesized by enzymes encoded by genes that are clustered in the genome. The vast majority of SM biosynthetic gene clusters are not expressed under normal growth conditions, and their products are unknow...

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Détails bibliographiques
Publié dans:ACS Chem Biol
Auteurs principaux: Grau, Michelle F., Entwistle, Ruth, Chiang, Yi-Ming, Ahuja, Manmeet, Oakley, C. Elizabeth, Akashi, Tomohiro, Wang, Clay C. C., Todd, Richard B., Oakley, Berl R.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546424/
https://ncbi.nlm.nih.gov/pubmed/30339758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00679
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