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Diacylglycerol kinase ζ is a negative regulator of GPVI-mediated platelet activation

Diacylglycerol kinases (DGKs) are a family of enzymes that convert diacylglycerol (DAG) into phosphatidic acid (PA). The ζ isoform of DGK (DGKζ) has been reported to inhibit T-cell responsiveness by downregulating intracellular levels of DAG. However, its role in platelet function remains undefined....

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Moroi, Alyssa J., Zwifelhofer, Nicole M., Riese, Matthew J., Newman, Debra K., Newman, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457232/
https://ncbi.nlm.nih.gov/pubmed/30967391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018026328
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