Lyn, PKC-δ, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion

Protein kinase C-δ (PKC-δ) is expressed in platelets and activated downstream of protease-activated receptors (PARs) and glycoprotein VI (GPVI) receptors. We have previously shown that PKC-δ positively regulates PAR-mediated dense granule secretion, whereas it negatively regulates GPVI-mediated dens...

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Détails bibliographiques
Auteurs principaux: Chari, Ramya, Kim, Soochong, Murugappan, Swaminathan, Sanjay, Archana, Daniel, James L., Kunapuli, Satya P.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2009
Sujets:
Platelets and Thrombopoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756209/
https://ncbi.nlm.nih.gov/pubmed/19587372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-11-188516
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