Adeno-associated virus delivery of anti-HIV monoclonal antibodies can drive long-term virologic suppression

Long-term delivery of anti-HIV monoclonal antibodies (mAbs) using adeno-associated virus (AAV) vectors holds promise for the prevention and treatment of HIV infection. We describe a therapy trial in which four rhesus monkeys were infected with SHIV-AD8 for 86 weeks before receiving the AAV-encoded m...

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Publicat a:Immunity
Autors principals: Martinez-Navio, José M., Fuchs, Sebastian P., Pantry, Shara N., Lauer, William A., Duggan, Natasha N., Keele, Brandon F., Rakasz, Eva G., Gao, Guangping, Lifson, Jeffrey D., Desrosiers, Ronald C.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457122/
https://ncbi.nlm.nih.gov/pubmed/30850342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.02.005
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