Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis

Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across the blood-brain barrier, as well as intrinsic and acquired drug resistance. Augm...

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Publicat a:Acta Neuropathol Commun
Autors principals: Sundstrøm, Terje, Prestegarden, Lars, Azuaje, Francisco, Aasen, Synnøve Nymark, Røsland, Gro Vatne, Varughese, Jobin K., Bahador, Marzieh, Bernatz, Simon, Braun, Yannick, Harter, Patrick N., Skaftnesmo, Kai Ove, Ingham, Elizabeth S., Mahakian, Lisa M., Tam, Sarah, Tepper, Clifford G., Petersen, Kjell, Ferrara, Katherine W., Tronstad, Karl Johan, Lund-Johansen, Morten, Beschorner, Rudi, Bjerkvig, Rolf, Thorsen, Frits
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456988/
https://ncbi.nlm.nih.gov/pubmed/30971321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0712-8
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