DS-04 DOPAMINE ADDICTION IN GLIOBLASTOMA MULTIFORME DURING CHEMOTHERAPY IS MEDIATED BY A DRD2/β-ARRESTIN/AKT SIGNALING COMPLEX

Glioblastomas are highly resistant to therapy and carries a dismal prognosis. Standard of care includes surgery followed by radiotherapy (RT) with concurrent and adjuvant chemotherapy with temozolomide (TMZ). The addition of TMZ to RT increases the overall survival by approximately 3 months compared...

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Main Authors: Prestegarden, Lars, Johannessen, Tor-Christian, Grudic, Amra, Sundstrøm, Terje, Saed, Halala, Varughese, Jobin, Lund-Johansen, Morten, Bjerkvig, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218027/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou244.4
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