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DDIS-21. APPLICATION OF A FUNCTIONAL GENETICS APPROACH TO IDENTIFY PHARMACOLOGICAL INHIBITORS OF HIF-1α
Two phase III clinical trials with temozolomide (TMZ) in combination with bevacizumab for newly diagnosed glioblastoma multiforme (GBM) failed to demonstrate any survival benefit when compared to TMZ alone. Previous studies have shown that bevacizumab treatment increases intratumoral hypoxia followe...
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| Veröffentlicht in: | Neuro Oncol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692325/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.256 |
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