The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells

INTRODUCTION: Glioblastoma multiforme (GBM; World Health Organization astrocytoma grade IV) is the most frequent and most malignant primary brain tumor in adults. Despite multimodal therapy, all such tumors practically recur during the course of therapy, causing a median survival of only 14.6 months...

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Detalhes bibliográficos
Main Authors: Johannessen, Tor-Christian Aase, Prestegarden, Lars, Grudic, Amra, Hegi, Monika E., Tysnes, Berit Bølge, Bjerkvig, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578482/
https://ncbi.nlm.nih.gov/pubmed/23258843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos301
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