AR Signaling in Prostate Cancer Regulates a Feed-Forward Mechanism of Androgen Synthesis by Way of HSD3B1 Upregulation

3βHSD1 enzymatic activity is essential for synthesis of potent androgens from adrenal precursor steroids in prostate cancer. A germline variant in HSD3B1, the gene that encodes 3βHSD1, encodes for a stable enzyme, regulates adrenal androgen dependence, and is a predictive biomarker of poor clinical...

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Publicat a:Endocrinology
Autors principals: Hettel, Daniel, Zhang, Ao, Alyamani, Mohammad, Berk, Michael, Sharifi, Nima
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456955/
https://ncbi.nlm.nih.gov/pubmed/29850791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2018-00283
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