Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools

BACKGROUND: Imputation has become a standard approach in genome-wide association studies (GWAS) to infer in silico untyped markers. Although feasibility for common variants imputation is well established, we aimed to assess rare and ultra-rare variants’ imputation in an admixed Caribbean Hispanic po...

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Vydáno v:Front Genet
Hlavní autoři: Sariya, Sanjeev, Lee, Joseph H., Mayeux, Richard, Vardarajan, Badri N., Reyes-Dumeyer, Dolly, Manly, Jennifer J., Brickman, Adam M., Lantigua, Rafael, Medrano, Martin, Jimenez-Velazquez, Ivonne Z., Tosto, Giuseppe
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456789/
https://ncbi.nlm.nih.gov/pubmed/31001313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00239
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