Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics

IMPORTANCE: The present study identified potential genetic modifiers that may delay or accelerate age at onset of familial Alzheimer disease (AD) by examining age at onset in PSEN1 mutation carrier families, and further investigation of these modifiers may provide insight into the pathobiology of AD...

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Publié dans:JAMA Neurol
Auteurs principaux: Lee, Joseph H., Cheng, Rong, Vardarajan, Badri, Lantigua, Rafael, Reyes-Dumeyer, Dolly, Ortmann, Ward, Graham, Robert R., Bhangale, Tushar, Behrens, Timothy W., Medrano, Martin, Jiménez-Velázquez, Ivonne Z., Mayeux, Richard
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010776/
https://ncbi.nlm.nih.gov/pubmed/26214276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2015.1424
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