Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies

The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA) contribute independently to protection again...

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Publicado en:mBio
Main Authors: Gao, Jin, Couzens, Laura, Burke, David F., Wan, Hongquan, Wilson, Patrick, Memoli, Matthew J., Xu, Xiyan, Harvey, Ruth, Wrammert, Jens, Ahmed, Rafi, Taubenberger, Jeffery K., Smith, Derek J., Fouchier, Ron A. M., Eichelberger, Maryna C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456748/
https://ncbi.nlm.nih.gov/pubmed/30967460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00307-19
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