Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses

Seasonal epidemics caused by influenza virus are driven by antigenic changes (drift) in viral surface glycoproteins that allow evasion from preexisting humoral immunity. Antigenic drift is a feature of not only the hemagglutinin (HA), but also of neuraminidase (NA). We have evaluated the antigenic e...

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Main Authors: Sandbulte, Matthew R., Westgeest, Kim B., Gao, Jin, Xu, Xiyan, Klimov, Alexander I., Russell, Colin A., Burke, David F., Smith, Derek J., Fouchier, Ron A. M., Eichelberger, Maryna C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251064/
https://ncbi.nlm.nih.gov/pubmed/22143798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113801108
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