Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses

Seasonal epidemics caused by influenza virus are driven by antigenic changes (drift) in viral surface glycoproteins that allow evasion from preexisting humoral immunity. Antigenic drift is a feature of not only the hemagglutinin (HA), but also of neuraminidase (NA). We have evaluated the antigenic e...

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Detalhes bibliográficos
Main Authors: Sandbulte, Matthew R., Westgeest, Kim B., Gao, Jin, Xu, Xiyan, Klimov, Alexander I., Russell, Colin A., Burke, David F., Smith, Derek J., Fouchier, Ron A. M., Eichelberger, Maryna C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251064/
https://ncbi.nlm.nih.gov/pubmed/22143798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113801108
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