Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies

The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA) contribute independently to protection again...

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Veröffentlicht in:mBio
Hauptverfasser: Gao, Jin, Couzens, Laura, Burke, David F., Wan, Hongquan, Wilson, Patrick, Memoli, Matthew J., Xu, Xiyan, Harvey, Ruth, Wrammert, Jens, Ahmed, Rafi, Taubenberger, Jeffery K., Smith, Derek J., Fouchier, Ron A. M., Eichelberger, Maryna C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456748/
https://ncbi.nlm.nih.gov/pubmed/30967460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00307-19
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