Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice

Highly pathogenic H5N1 influenza shares the same neuraminidase (NA) subtype with the 2009 pandemic (H1N1pdm09), and cross-reactive NA immunity might protect against or mitigate lethal H5N1 infection. In this study, mice were either infected with a sublethal dose of H1N1pdm09 or were vaccinated and b...

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Detalhes bibliográficos
Main Authors: Easterbrook, Judith D., Schwartzman, Louis M., Gao, Jin, Kash, John C., Morens, David M., Couzens, Laura, Wan, Hongquan, Eichelberger, Maryna C., Taubenberger, Jeffery K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725556/
https://ncbi.nlm.nih.gov/pubmed/22727831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.06.003
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