The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces in vivo Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels

Chemogenetic studies with the ligand clozapine N-oxide (CNO) are predicated upon the assumption that CNO is devoid of actions at natural neuroreceptors. However, recent evidence shows that CNO may be converted back to clozapine (CLZ) in vivo, which could yield plasma concentrations that may be suffi...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Bærentzen, Simone, Casado-Sainz, Agata, Lange, Denise, Shalgunov, Vladimir, Tejada, Isabel Martinez, Xiong, Mengfei, L’Estrade, Elina T., Edgar, Fraser G., Lee, Hedok, Herth, Matthias M., Palner, Mikael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456655/
https://ncbi.nlm.nih.gov/pubmed/31001069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00187
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