The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces in vivo Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels

Chemogenetic studies with the ligand clozapine N-oxide (CNO) are predicated upon the assumption that CNO is devoid of actions at natural neuroreceptors. However, recent evidence shows that CNO may be converted back to clozapine (CLZ) in vivo, which could yield plasma concentrations that may be suffi...

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Dades bibliogràfiques
Publicat a:Front Neurosci
Autors principals: Bærentzen, Simone, Casado-Sainz, Agata, Lange, Denise, Shalgunov, Vladimir, Tejada, Isabel Martinez, Xiong, Mengfei, L’Estrade, Elina T., Edgar, Fraser G., Lee, Hedok, Herth, Matthias M., Palner, Mikael
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456655/
https://ncbi.nlm.nih.gov/pubmed/31001069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00187
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