Alagebrium targets the miR-27b/TSP-1 signaling pathway to rescue N(ε)-carboxymethyl-lysine-induced endothelial dysfunction

N(ε)-carboxymethyl-lysine (CML), a major isoform of advanced glycation end products (AGEs), plays a crucial role in the functional damage of diabetes mellitus. However, it is not clear whether ALT-711 (alagebrium), an inhibitor of AGEs, is capable to rescue CML-induced poor angiogenesis, as well as...

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Bibliografische gegevens
Gepubliceerd in:Am J Transl Res
Hoofdauteurs: Chen, Yihong, Niu, Wenhao, Chao, Yu-Chieh, He, Zhiqing, Ding, Ru, Wu, Feng, Liang, Chun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: e-Century Publishing Corporation 2019
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6456531/
https://ncbi.nlm.nih.gov/pubmed/30972183
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