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The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2B(Intron5)-associated toxicity in animal models of frontotemporal dementia
Frontotemporal dementia (FTD) is one of the most prevalent forms of early-onset dementia. However, the pathological mechanisms driving neuronal atrophy in FTD remain poorly understood. Here we identify a conserved role for the novel pro-apoptotic protein plenty of SH3s (POSH)/SH3 domain containing r...
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| 發表在: | Hum Mol Genet |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6454437/ https://ncbi.nlm.nih.gov/pubmed/29432529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy048 |
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