A Small Molecule SIRT2 Inhibitor that Promotes K-Ras4a Lysine Fatty-acylation

SIRT2 a member of the sirtuin family of protein lysine deacylases has been identified as a promising therapeutic target. In addition to catalyzing deacetylation, SIRT2 has recently been shown to remove fatty acyl groups from K-Ras4a and promote its transforming activity. Among the SIRT2 specific inh...

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Publicat a:ChemMedChem
Autors principals: Spiegelman, Nicole A., Hong, Jun Young, Hu, Jing, Jing, Hui, Wang, Miao, Price, Ian R., Cao, Ji, Yang, Min, Zhang, Xiaoyu, Lin, Hening
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452895/
https://ncbi.nlm.nih.gov/pubmed/30734528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800715
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