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A Small Molecule SIRT2 Inhibitor that Promotes K-Ras4a Lysine Fatty-acylation
SIRT2 a member of the sirtuin family of protein lysine deacylases has been identified as a promising therapeutic target. In addition to catalyzing deacetylation, SIRT2 has recently been shown to remove fatty acyl groups from K-Ras4a and promote its transforming activity. Among the SIRT2 specific inh...
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| Publicado no: | ChemMedChem |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6452895/ https://ncbi.nlm.nih.gov/pubmed/30734528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800715 |
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