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Human disease mutations highlight the inhibitory function of TIM-3
A new study identifies loss-of-function mutations in HAVCR2, which encodes TIM-3, in patients with a rare cutaneous T cell lymphoma associated with aberrant immunological activation. These mutations lead to loss of the TIM-3 immunological checkpoint, thus promoting inflammation and malignancy.
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| Publicado no: | Nat Genet |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6452640/ https://ncbi.nlm.nih.gov/pubmed/30405215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0289-3 |
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