The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

The Sec61-complex as a dynamic polypeptide-conducting channel mediates protein transport into the human endoplasmic reticulum (ER) with the help of additional components. ER membrane resident Hsp40-type co-chaperone Sec63 as well as the ER lumenal Hsp70-type chaperone BiP were proposed to facilitate...

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Detalhes bibliográficos
Publicado no:Biol Open
Main Authors: Ziska, Anke, Tatzelt, Jörg, Dudek, Johanna, Paton, Adrienne W., Paton, James C., Zimmermann, Richard, Haßdenteufel, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451349/
https://ncbi.nlm.nih.gov/pubmed/30745438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.040691
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