Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the heterotrimeric Sec61 channel. The signal recognition particle (SRP) and TRC systems and Sec62 have all been characterized as membrane-targeting components for small presecretory proteins, whereas Sec63 and the lumenal...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Haßdenteufel, Sarah, Johnson, Nicholas, Paton, Adrienne W., Paton, James C., High, Stephen, Zimmermann, Richard
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946456/
https://ncbi.nlm.nih.gov/pubmed/29719251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.122
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