Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the heterotrimeric Sec61 channel. The signal recognition particle (SRP) and TRC systems and Sec62 have all been characterized as membrane-targeting components for small presecretory proteins, whereas Sec63 and the lumenal...

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Vydáno v:Cell Rep
Hlavní autoři: Haßdenteufel, Sarah, Johnson, Nicholas, Paton, Adrienne W., Paton, James C., High, Stephen, Zimmermann, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946456/
https://ncbi.nlm.nih.gov/pubmed/29719251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.122
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