Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

Co-translational transport of polypeptides into the endoplasmic reticulum (ER) involves the Sec61 channel and additional components such as the ER lumenal Hsp70 BiP and its membrane-resident co-chaperone Sec63p in yeast. We investigated whether silencing the SEC61A1 gene in human cells affects co- a...

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Detalhes bibliográficos
Main Authors: Lang, Sven, Benedix, Julia, Fedeles, Sorin V., Schorr, Stefan, Schirra, Claudia, Schäuble, Nico, Jalal, Carolin, Greiner, Markus, Haßdenteufel, Sarah, Tatzelt, Jörg, Kreutzer, Birgit, Edelmann, Ludwig, Krause, Elmar, Rettig, Jens, Somlo, Stefan, Zimmermann, Richard, Dudek, Johanna
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074215/
https://ncbi.nlm.nih.gov/pubmed/22375059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.096727
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