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Impaired transport of intrinsically disordered proteins through the Sec61 and SecY translocon; implications for prion diseases
The prion protein (PrP) is composed of two major domains of similar size. The structured C-terminal domain contains three alpha-helical regions and a short two-stranded beta-sheet, while the N-terminal domain is intrinsically disordered. The analysis of PrP mutants with deletions in the C-terminal g...
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| Publicado en: | Prion |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6016518/ https://ncbi.nlm.nih.gov/pubmed/29388511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2018.1435936 |
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