CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs

Chain-terminating nucleoside analogs (CTNAs), which cannot be extended by DNA polymerases, are widely used as antivirals or anti-cancer agents, and can induce cell death. Processing of blocked DNA ends, like camptothecin-induced trapped-topoisomerase I, can be mediated by TDP1, BRCA1, CtIP and MRE11...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Mohiuddin, Mohiuddin, Rahman, Md Maminur, Sale, Julian E, Pearson, Christopher E
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451104/
https://ncbi.nlm.nih.gov/pubmed/30657944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz009
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