High Skp2 expression is associated with a mesenchymal phenotype and increased tumorigenic potential of prostate cancer cells

Skp2 is a crucial component of SCF(Skp2) E3 ubiquitin ligase and is often overexpressed in various types of cancer, including prostate cancer (PCa). The epithelial-to-mesenchymal transition (EMT) is involved in PCa progression. The acquisition of a mesenchymal phenotype that results in a cancer stem...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Šimečková, Šárka, Kahounová, Zuzana, Fedr, Radek, Remšík, Ján, Slabáková, Eva, Suchánková, Tereza, Procházková, Jiřina, Bouchal, Jan, Kharaishvili, Gvantsa, Král, Milan, Beneš, Petr, Souček, Karel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6451010/
https://ncbi.nlm.nih.gov/pubmed/30952903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42131-y
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