Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells. Here we show that androgen deprivation therapy (ADT), a...

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Detaylı Bibliyografya
Asıl Yazarlar: Pernicová, Zuzana, Slabáková, Eva, Kharaishvili, Gvantsa, Bouchal, Jan, Král, Milan, Kunická, Zuzana, Machala, Miroslav, Kozubík, Alois, Součcek, Karel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press Inc. 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114246/
https://ncbi.nlm.nih.gov/pubmed/21677876
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