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Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2
Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells. Here we show that androgen deprivation therapy (ADT), a...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2011-06-01
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| Colecção: | Neoplasia: An International Journal for Oncology Research |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S1476558611800448 |
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