Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks

DNA double-strand break (DSB) signaling and repair are critical for genome integrity. They rely on highly coordinated processes including posttranslational modifications of proteins. Here we show that Pellino1 (Peli1) is a DSB-responsive ubiquitin ligase required for the accumulation of DNA damage r...

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Publicado no:Nat Commun
Main Authors: Ha, Geun-Hyoung, Ji, Jae-Hoon, Chae, Sunyoung, Park, Jihyun, Kim, Suhyeon, Lee, Jin-Kwan, Kim, Yonghyeon, Min, Sunwoo, Park, Jeong-Min, Kang, Tae-Hong, Lee, Ho, Cho, Hyeseong, Lee, Chang-Woo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450972/
https://ncbi.nlm.nih.gov/pubmed/30952868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09641-9
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