Differences in stability, activity and mutation effects between human and mouse Leucine-Rich Repeat Kinase 2

Mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene have been implicated in the pathogenesis of Parkinson’s disease (PD). Identification of PD-associated LRRK2 mutations has led to the development of novel animal models, primarily in mice. However, the characteristics of human LRRK2 and mouse...

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I publikationen:Neurochem Res
Huvudupphovsmän: Langston, Rebekah G., Rudenko, Iakov N., Kumaran, Ravindran, Hauser, David N., Kaganovich, Alice, Ponce, Luis Bonet, Mamais, Adamantios, Ndukwe, Kelechi, Dillman, Allissa A., Al-Saif, Amr M., Beilina, Aleksandra, Cookson, Mark R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450775/
https://ncbi.nlm.nih.gov/pubmed/30291536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-018-2650-4
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