Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are a common genetic cause of Parkinson disease, but the mechanisms whereby LRRK2 is regulated are unknown. Phosphorylation of LRRK2 at Ser(910)/Ser(935) mediates interaction with 14-3-3. Pharmacological inhibition of its kinase act...

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Detalhes bibliográficos
Main Authors: Mamais, Adamantios, Chia, Ruth, Beilina, Alexandra, Hauser, David N., Hall, Christine, Lewis, Patrick A., Cookson, Mark R., Bandopadhyay, Rina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118103/
https://ncbi.nlm.nih.gov/pubmed/24942733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528463
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