The mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation and mRNA export

Alternative polyadenylation (APA) produces mRNA isoforms with different 3’UTR lengths. Previous studies indicated that 3’ end processing and mRNA export are intertwined in gene regulation. Here, we show that mRNA export factors generally facilitate usage of distal cleavage and polyadenylation sites...

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Udgivet i:Mol Cell
Main Authors: Chen, Suli, Wang, Ruijia, Zheng, Dinghai, Zhang, Heng, Chang, Xingya, Wang, Ke, Li, Wencheng, Fan, Jing, Tian, Bin, Cheng, Hong
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450743/
https://ncbi.nlm.nih.gov/pubmed/30819645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.026
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