Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers

Substrate-binding proteins (SBPs) are associated with ATP-binding cassette importers and switch from an open to a closed conformation upon substrate binding, providing specificity for transport. We investigated the effect of substrates on the conformational dynamics of six SBPs and the impact on tra...

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Udgivet i:eLife
Main Authors: de Boer, Marijn, Gouridis, Giorgos, Vietrov, Ruslan, Begg, Stephanie L, Schuurman-Wolters, Gea K, Husada, Florence, Eleftheriadis, Nikolaos, Poolman, Bert, McDevitt, Christopher A, Cordes, Thorben
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450668/
https://ncbi.nlm.nih.gov/pubmed/30900991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44652
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