Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib

The third-generation tyrosine kinase inhibitor (TKI) ponatinib has been associated with high rates of acute ischemic events. The pathophysiology responsible for these events is unknown. We hypothesized that ponatinib produces an endothelial angiopathy involving excessive endothelial-associated von W...

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Vydáno v:Blood
Hlavní autoři: Latifi, Yllka, Moccetti, Federico, Wu, Melinda, Xie, Aris, Packwood, William, Qi, Yue, Ozawa, Koya, Shentu, Weihui, Brown, Eran, Shirai, Toshiaki, McCarty, Owen J., Ruggeri, Zaverio, Moslehi, Javid, Chen, Junmei, Druker, Brian J., López, Jose A., Lindner, Jonathan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450432/
https://ncbi.nlm.nih.gov/pubmed/30692122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-10-881557
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