The DNase Activity of Kaposi’s Sarcoma-Associated Herpesvirus SOX Protein Serves an Important Role in Viral Genome Processing during Lytic Replication

The Kaposi's sarcoma-associated herpesvirus (KSHV) alkaline exonuclease SOX, encoded by open reading frame 37 (ORF37), is a bifunctional early-lytic-phase protein that possesses alkaline 5′-to-3′ DNase activity and promotes host shutoff at the mRNA level during productive lytic infection. While...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Uppal, Timsy, Meyer, Dylan, Agrawal, Andrea, Verma, Subhash C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2019
Onderwerpen:
Genome Replication and Regulation of Viral Gene Expression
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450125/
https://ncbi.nlm.nih.gov/pubmed/30728255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01983-18
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