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Kaposi's Sarcoma-Associated Herpesvirus Deregulates Host Cellular Replication during Lytic Reactivation by Disrupting the MCM Complex through ORF59

Minichromosome maintenance proteins (MCMs) play an important role in DNA replication by binding to the origins as helicase and recruiting polymerases for DNA synthesis. During the S phase, MCM complex is loaded to limit DNA replication once per cell cycle. We identified MCMs as ORF59 binding partner...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Virol
Main Authors: Strahan, Roxanne, Dabral, Prerna, Dingman, Kammi, Stadler, Christian, Hiura, Kayla, Verma, Subhash C.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206491/
https://ncbi.nlm.nih.gov/pubmed/30158293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00739-18
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