Prediction of lefamulin epithelial lining fluid penetration after intravenous and oral administration using Phase 1 data and population pharmacokinetics methods

OBJECTIVES: Lefamulin is a semi-synthetic intravenous and oral pleuromutilin antibiotic with activity against pathogens commonly associated with community-acquired bacterial pneumonia. Using data from two Phase 1 studies, a population pharmacokinetics (PPK) model for lefamulin in plasma and epitheli...

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Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Zhang, Li, Wicha, Wolfgang W, Bhavnani, Sujata M, Rubino, Christopher M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Supplement Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449575/
https://ncbi.nlm.nih.gov/pubmed/30949708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz088
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