Zanamivir Pharmacokinetics and Pulmonary Penetration into Epithelial Lining Fluid following Intravenous or Oral Inhaled Administration to Healthy Adult Subjects

Zanamivir serum and pulmonary pharmacokinetics were characterized following intravenous (i.v.) or oral inhaled administration. I.v. zanamivir was given as intermittent doses of 100 mg, 200 mg, and 600 mg every 12 h (q12h) for two doses or as a continuous infusion (6-mg loading dose followed by 3 mg/...

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Detalhes bibliográficos
Main Authors: Shelton, Mark J., Lovern, Mark, Ng-Cashin, Judith, Jones, Lori, Gould, Elizabeth, Gauvin, Jennifer, Rodvold, Keith A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195002/
https://ncbi.nlm.nih.gov/pubmed/21896909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00703-11
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