Evaluation of Tigecycline Penetration into Colon Wall Tissue and Epithelial Lining Fluid Using a Population Pharmacokinetic Model and Monte Carlo Simulation

The objective of these analyses was to assess the penetration of tigecycline into colon wall tissue and epithelial lining fluid (ELF). The analyses included data from subjects without infection (phase 1) and patients with intra-abdominal infections (phase 2/3). Steady-state serum samples were collec...

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Detalhes bibliográficos
Main Authors: Rubino, Christopher M., Ma, Lei, Bhavnani, Sujata M., Korth-Bradley, Joan, Speth, John, Ellis-Grosse, Evelyn, Rodvold, Keith R., Ambrose, Paul G., Drusano, George L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151455/
https://ncbi.nlm.nih.gov/pubmed/17846139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00065-07
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