Reversible induction of mitophagy by an optogenetic bimodular system

Autophagy-mediated degradation of mitochondria (mitophagy) is a key process in cellular quality control. Although mitophagy impairment is involved in several patho-physiological conditions, valuable methods to induce mitophagy with low toxicity in vivo are still lacking. Herein, we describe a new op...

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Udgivet i:Nat Commun
Main Authors: D’Acunzo, Pasquale, Strappazzon, Flavie, Caruana, Ignazio, Meneghetti, Giacomo, Di Rita, Anthea, Simula, Luca, Weber, Gerrit, Del Bufalo, Francesca, Dalla Valle, Luisa, Campello, Silvia, Locatelli, Franco, Cecconi, Francesco
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449392/
https://ncbi.nlm.nih.gov/pubmed/30948710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09487-1
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