AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

Therapeutic strategies are needed to protect dopaminergic neurons in Parkinson’s disease (PD) patients. Oxidative stress caused by dopamine may play an important role in PD pathogenesis. Selective autophagy of mitochondria (mitophagy), mainly regulated by PINK1 and PARKIN, plays an important role in...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Di Rita, Anthea, D’Acunzo, Pasquale, Simula, Luca, Campello, Silvia, Strappazzon, Flavie, Cecconi, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932353/
https://ncbi.nlm.nih.gov/pubmed/29755319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00092
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