AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

Therapeutic strategies are needed to protect dopaminergic neurons in Parkinson’s disease (PD) patients. Oxidative stress caused by dopamine may play an important role in PD pathogenesis. Selective autophagy of mitochondria (mitophagy), mainly regulated by PINK1 and PARKIN, plays an important role in...

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Publicat a:Front Cell Neurosci
Autors principals: Di Rita, Anthea, D’Acunzo, Pasquale, Simula, Luca, Campello, Silvia, Strappazzon, Flavie, Cecconi, Francesco
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932353/
https://ncbi.nlm.nih.gov/pubmed/29755319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00092
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