AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

Therapeutic strategies are needed to protect dopaminergic neurons in Parkinson’s disease (PD) patients. Oxidative stress caused by dopamine may play an important role in PD pathogenesis. Selective autophagy of mitochondria (mitophagy), mainly regulated by PINK1 and PARKIN, plays an important role in...

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Detalhes bibliográficos
Main Authors: Anthea Di Rita, Pasquale D’Acunzo, Luca Simula, Silvia Campello, Flavie Strappazzon, Francesco Cecconi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-04-01
Colecção:Frontiers in Cellular Neuroscience
Assuntos:
cell death
oxidative stress
in vitro models
Parkinson’s disease
mitophagy
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fncel.2018.00092/full
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