AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

Therapeutic strategies are needed to protect dopaminergic neurons in Parkinson’s disease (PD) patients. Oxidative stress caused by dopamine may play an important role in PD pathogenesis. Selective autophagy of mitochondria (mitophagy), mainly regulated by PINK1 and PARKIN, plays an important role in...

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Bibliografiska uppgifter
I publikationen:Front Cell Neurosci
Huvudupphovsmän: Di Rita, Anthea, D’Acunzo, Pasquale, Simula, Luca, Campello, Silvia, Strappazzon, Flavie, Cecconi, Francesco
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2018
Ämnen:
Neuroscience
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932353/
https://ncbi.nlm.nih.gov/pubmed/29755319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00092
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